| Bioactivity | Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM[1][2][3]. |
| CAS | 53439-81-9 |
| Formula | C12H8N2O |
| Molar Mass | 196.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. [2]. Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. [3]. Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7. |
Benzo[c][1,8]naphthyridin-6(5H)-one
CAS: 53439-81-9 F: C12H8N2O W: 196.20
Benzonaphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.
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